Cerebral Invasion Mac OS

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Abstract

Concussion diagnosis is characterized by a lack of objective markers, as there is a paucity of better understanding of the pathophysiology. Cerebral vasoreactivity (CVR), an important factor in cerebral blood flow (CBF) regulation with dynamic changes in metabolism can be assessed utilizing manipulation of arterial carbon dioxide. CVR utilizing transcranial Doppler ultrasonography may be a useful, objective vascular biomarker for physiological recovery. PURPOSE: To determine the link between clinical symptoms and CVR on Day-3, Day-21, and Day-90 following a concussion in comparison to the non-injured controls. METHODS: Twenty-seven male and female collegiate athletes (21 ±1years) sustaining a sports-related concussion were enrolled. Age and sports-matched non-injured controls were also enrolled. For the concussed athletes, data were obtained on Day-3, Day-21, and Day-90 (N= 17) following the head injury. Symptom severity and cognition were assessed using the Sports Concussion Assessment Tool-3rd Edition (SCAT-3). Depression was assessed utilizing the Patient Health Questionnaire (PHQ-9). Continuous middle cerebral artery blood flow velocity (MCAV) was obtained with transcranial Doppler ultrasonography (TCD) while subjects were seated in an upright position. End-tidal CO₂ (PetCO₂) was measured with an infrared CO₂ analyzer attached to a nasal cannula. MCAV was evaluated in response to changes in PetCO₂ for 2-minutes each during normal breathing (normocapnia), inspiring a gas mixture containing 8% CO₂, 21% oxygen (hypercapnia), and hyperventilating (hypocapnia). RESULTS: On Day-3 subsequent to the head injury, concussed athletes displayed higher symptom number (2.5±3 vs. 12.1±7; PCONCLUSION: Elevated symptoms and lower cognitive scores on Day-3 were resolved by Day-21 following a sports-related concussion. On the other hand, CVR remained impaired at 90 days following concussion suggesting persistent physiological impairment beyond symptom resolution, which could accentuate secondary injuries during this phase. Future studies with a large sample size and longer follow-up period are needed to validate the use of CVR as an objective marker.

Recommended Citation

Lyng, Sydney H.; Frantz, Justin; Wainman, Madeline; Sabo, Tonia; Bell, Kathleen; and Purkayastha, Sushmita (2018) 'Persistent Impairment in Cerebral Vasoreactivity in Subacute Phase Following Concussion,' International Journal of Exercise Science: Conference Proceedings: Vol. 2 : Iss. 10 , Article 26.
Available at: https://digitalcommons.wku.edu/ijesab/vol2/iss10/26

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(Redirected from OttoMatic)
Invasion
Otto Matic
Developer(s)Pangea Software
Ideas From the Deep (PC)
Publisher(s)Aspyr Media(Mac)
Ideas From the Deep (PC)
Pangea Software (iOS)
Platform(s)Mac OS 8, Mac OS 9, Mac OS X, Microsoft Windows, iPhone OS
Release
  • Macintosh
    • NA: December 4, 2001[1]
    Microsoft Windows
    • WW: February 23, 2004 (Online)[3]
    • NA: February 23, 2005 (Retail)[2]
    iPhone OS
Genre(s)Action-adventure[5]
Mode(s)Single player

Otto Matic is a 2001 action-adventurevideo game developed by Pangea Software and published by Aspyr Media for Mac OS 8,Mac OS 9 and Mac OS X. It came bundled with iMac G3 and G4 computers. The game was later ported by Ideas From the Deep to Microsoft Windows in 2004. An iPhone OS port, titled Otto Matic: Alien Invasion, was released by Pangea in 2009.

Otto Matic parodies the retro science fiction genre in a whimsical style.[6] Its gameplay resembles that of Pangea's previous titles like Bugdom and Nanosaur.

Gameplay[edit]

The gameplay of Otto Matic is level-based, and the player's success on a level is measured with points. Levels typically begin with Otto landing his rocket ship on a planet controlled by the Brain Aliens. As soon as Otto has disembarked, the rocket ship promptly takes off again and lands at the end of the level. To progress to the next level, the player must return to the rocket ship with enough fuel for take off. The majority of the game's points are scored by saving humans from abduction, although some points are also awarded for finding weapons and ammunition.

Cerebral Invasion Mac Os Catalina

The levels include power-ups such as weapons, health, rocket fuel and jump-jet fuel, and occasionally brief vehicle sections. The level design tends towards the whimsical: enemies include enormous walking vegetables, clowns, and miniature robotic wrecking balls, and the landscapes are usually cartoonish and warped.

Plot[edit]

Otto Matic takes place in the year 1957, as the Earth is being conquered by the evil Brain Aliens from Planet X. The people of Earth are being systematically abducted by the flying saucers of the Brain Aliens, who wish to transform the humans into new Brain Aliens, subject to the will of their leader, the Giant Brain.

The player takes on the role of Otto Matic, one of a line of robots charged with policing the galaxy, as he attempts to defeat the Brain Aliens and restore the independence of the Earth. Otto travels to eight planets and rescues the humans, defeating the Giant Brain in a final confrontation.

References[edit]

  1. ^'Otto Matic Ships, Demo Out'. Inside Mac Games. December 4, 2001. Retrieved February 2, 2015.CS1 maint: discouraged parameter (link)
  2. ^'Otto Matic in Retail'. Ideas From the Deep. February 21, 2005. Retrieved February 2, 2015.CS1 maint: discouraged parameter (link)
  3. ^'New Products'. Ideas From the Deep. Retrieved February 2, 2015.CS1 maint: discouraged parameter (link)
  4. ^'Otto Matic: Alien Invasion Released Tonight!!'. Andy’s Reviews of iPhone Games and More. March 6, 2009. Retrieved February 2, 2015.CS1 maint: discouraged parameter (link)
  5. ^'Otto Matic'. Pangea Software. Retrieved January 12, 2015.CS1 maint: discouraged parameter (link)
  6. ^'Otto Matic: Alien Invasion Attacks the iPhone and iPod Touch'. IGN. April 1, 2009. Retrieved February 2, 2015.CS1 maint: discouraged parameter (link)
Cerebral

External links[edit]

Cerebral Invasion Mac Os X

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